2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester

Base Information

• Chemical Name: 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester
• CAS No.: 175548-89-7
• Molecular Formula: C₁₇H₂₂F₂N₂O₅
• Molecular Weight: 372.369
• Mol file: 175548-89-7.mol

Synonyms:2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester

Chemical Property of 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester

There total 4 articles about 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Benzyloxycarbonylamino-2,2-difluoro-pentanedioic acid di-tert-butyl ester (175548-84-2) → 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester (175548-89-7)

Guidance literature:

With ammonia; In methanol; water; for 7h; Ambient temperature;

DOI:10.1021/jo952044+

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester (175548-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaHCO₃ / H₂O / 9 h / Ambient temperature

2: 89 percent / sulfuric acid / CH₂Cl₂ / 120 h / Ambient temperature

3: 80 percent / ammonia / H₂O; methanol / 7 h / Ambient temperature

With sulfuric acid; ammonia; sodium hydrogencarbonate; In methanol; dichloromethane; water;

DOI:10.1021/jo952044+

Reference yield:

DL-4,4-difluoroglutamic acid (173282-21-8) → 2-Benzyloxycarbonylamino-4-carbamoyl-4,4-difluoro-butyric acid tert-butyl ester (175548-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaHCO₃ / H₂O / 9 h / Ambient temperature

2: 89 percent / sulfuric acid / CH₂Cl₂ / 120 h / Ambient temperature

3: 80 percent / ammonia / H₂O; methanol / 7 h / Ambient temperature

With sulfuric acid; ammonia; sodium hydrogencarbonate; In methanol; dichloromethane; water;

DOI:10.1021/jo952044+

upstream raw materials:

4-Benzyloxycarbonylamino-2,2-difluoro-pentanedioic acid di-tert-butyl ester

benzyl chloroformate

DL-4,4-difluoroglutamic acid

N-benzyloxycarbonyl-4,4-difluoroglutamic acid