Technology Process of cis-(1R,2R)-1-formyl-2-<(E)-hex-1-enyl>cyclopropane
There total 21 articles about cis-(1R,2R)-1-formyl-2-<(E)-hex-1-enyl>cyclopropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
molecular sieve; sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
for 0.5h;
Ambient temperature;
DOI:10.1016/S0040-4020(01)86378-X
- Guidance literature:
-
Multi-step reaction with 7 steps
1: LAH / diethyl ether / 0.5 h / 0 °C
2: DMAP, TEA / CH2Cl2 / 1 h / Ambient temperature
3: 1M NaOH / ethane-1,2-diol; H2O / 3 °C / lipase (PPL)
4: PCC, NaOAc, molecular sieves / CH2Cl2 / 1 h / Ambient temperature
5: 1) NaHMDS / 1) -178 deg C (5 min) to r.t., 2) 110 dec C, 30 min
6: 90 percent / K2CO3, MeOH / 0.42 h / Ambient temperature
7: 85 percent / PCC, NaOAc, molecular sieves / CH2Cl2 / 0.5 h / Ambient temperature
With
methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; molecular sieve; TEA; sodium acetate; sodium hexamethyldisilazane; potassium carbonate; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; water; ethylene glycol;
DOI:10.1016/S0040-4020(01)86378-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: imidazole / dimethylformamide / 25 °C
2: EtMgBr / dimethylformamide / 2 h / Ambient temperature
3: DMAP, NEt3 / CH2Cl2 / 0.33 h / Ambient temperature
4: (Bu)4N(1+)*F(1-) / tetrahydrofuran / 1.25 h / Ambient temperature
5: H2 / Pd/Lindlar / methanol
6: DBU, 5percent Pd(dppe)2 / tetrahydrofuran / 1.25 h / 25 °C
8: 80 percent / Pd(dppe)2
With
1H-imidazole; dmap; bis[1,2-bis(diphenylphosphino)ethane]palladium(0); ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
Lindlar's catalyst; bis[1,2-bis(diphenylphosphino)ethane]palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94910-4
