diethyl 2-benzylamino-2-malonate

Base Information

• Chemical Name: diethyl 2-benzylamino-2-malonate
• CAS No.: 159530-78-6
• Molecular Formula: C₂₅H₂₇N₅O₇
• Molecular Weight: 509.519
• Mol file: 159530-78-6.mol

Synonyms:diethyl 2-benzylamino-2-malonate

Chemical Property of diethyl 2-benzylamino-2-malonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of diethyl 2-benzylamino-2-malonate

There total 1 articles about diethyl 2-benzylamino-2-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-malonate (155568-39-1) + benzylamine (100-46-9) → diethyl 2-benzylamino-2-malonate (159530-78-6)

Guidance literature:

With bromine; sodium hydride; Multistep reaction; 1.) THF, -78 deg C;

DOI:10.1016/0040-4039(94)85016-X

Reference yield: 79.0%

diethyl 2-benzylamino-2-malonate (159530-78-6) → diethyl 2-benzylamino-2-malonate (159530-79-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1080/15257779508012405

Reference yield:

diethyl 2-benzylamino-2-malonate (159530-78-6) → 3-benzyl-4,5,7,8-tetrahydro-6-methoxy-6-methoxycarbonyl-6H-imidazo<4,5-e><1,4>diazepine-5,8-dione (155568-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / H₂ / 10percent Pd/C / methanol / 0.58 h / 2068.6 Torr

2: methanol / 2.5 h / Heating

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1080/00397919508011820

upstream raw materials:

diethyl 2-malonate

benzylamine

Downstream raw materials:

diethyl 2-benzylamino-2-malonate

3-benzyl-4,5,7,8-tetrahydro-6-methoxy-6-methoxycarbonyl-6H-imidazo<4,5-e><1,4>diazepine-5,8-dione

6-Amino-3-benzyl-5,8-dioxo-3,4,5,6,7,8-hexahydro-imidazo[4,5-e][1,4]diazepine-6-carboxylic acid methyl ester