2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

Base Information

Chemical Name:2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone
CAS No.:159425-50-0
Molecular Formula:C₃₅H₄₆O₉Si
Molecular Weight:638.83
Hs Code.:

Synonyms:2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

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Chemical Property of 2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

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Technology Process of 2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

There total 10 articles about 2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 159425-49-7
1-<<2-(1,3-dioxanyl)-6-(benzyloxy)phenyl>hydroxymethyl>-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

: 159425-50-0
2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/jo00101a032

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 159425-50-0
2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

2: 100 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 87 percent / imidazole / CH₂Cl₂

4: 73 percent / n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 60 min, 2.) 0 deg C, 2 h; r.t., overnight

5: 93 percent / MnO₂ / CH₂Cl₂ / 48 h / Ambient temperature

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo00101a032

Reference yield:

: 1700-30-7
(3-(benzyloxy)phenyl)methanol

: 159425-50-0
2-(1,3-dioxanyl)-6'-(benzyloxy)-2,6-bis(methoxymethoxy)-4-<<(tert-butyldimethylsilyl)oxy>methyl>benzophenone

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / n-BuLi, BrF₂CH₂CH₂F₂Br / toluene / -20 °C

2: 90 percent / NaBr, NaOCl, TEMPO / tetrahydrofuran / 3 h / 0 °C

3: 96 percent / p-TSA*H₂O / toluene / 1.5 h / Heating

4: 79 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -60 deg C, 15 min, 2.) -65 deg C, 4 h; r.t., 16 h

5: 73 percent / n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 60 min, 2.) 0 deg C, 2 h; r.t., overnight

6: 93 percent / MnO₂ / CH₂Cl₂ / 48 h / Ambient temperature

With manganese(IV) oxide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; n-butyllithium; BrF₂CH₂CH₂F₂Br; toluene-4-sulfonic acid; sodium bromide; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/jo00101a032