N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

Base Information

Chemical Name:N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide
CAS No.:1363160-97-7
Molecular Formula:C₁₇H₁₈N₆O₂
Molecular Weight:338.369
Hs Code.:

Synonyms:N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

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Chemical Property of N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

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Technology Process of N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

There total 12 articles about N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1415905-42-8
1-(3-aminophenyl)-3-methyl-7-(methylamino)-3,4-dihydropyrimidino[4,5-d]pyrimidin-2(1H)-one

: 814-68-6,25189-84-8
acryloyl chloride

: 1363160-97-7
N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1363160-97-7
N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -40 - 20 °C

3.1: sodium acetate / methanol / 1 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: sodium acetate / 1,4-dioxane / 24 h / 100 °C / Sealed tube

7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1363161-15-2
tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1363160-97-7
N-(3-(3-methyl-7-(methylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl) phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate / methanol / 1 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

4.1: sodium acetate / 1,4-dioxane / 24 h / 100 °C / Sealed tube

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;