5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine

Base Information

• Chemical Name: 5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine
• CAS No.: 1229662-55-8
• Molecular Formula: C₃₆H₃₅N₃O₂Si
• Molecular Weight: 569.778

Synonyms:5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine

Chemical Property of 5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine

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Technology Process of 5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine

There total 1 articles about 5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-(trimethylsilyl)-1-(trityloxy)pent-4-yn-2-ol (1229662-53-6) + 3-(methylsulfonyl)-5-phenyl-1,2,4-triazine (83413-00-7) → 5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine (1229662-55-8)

Guidance literature:

5-(trimethylsilyl)-1-(trityloxy)pent-4-yn-2-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.5h;

3-(methylsulfonyl)-5-phenyl-1,2,4-triazine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

DOI:10.1055/s-0029-1218665

Reference yield: 93.0%

5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine (1229662-55-8) → 5-phenyl-3-[1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine (1229662-59-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1055/s-0029-1218665

Reference yield: 89.0%

5-phenyl-3-[4-(trimethylsilyl)-1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine (1229662-55-8) → 6-phenyl-4-(trimethylsilyl)-2-(trityloxymethyl)-2,3-dihydrofuro[2,3-b]pyridine (1229662-61-6)

Guidance literature:

In chlorobenzene; at 170 ℃; under 2250.23 - 4500.45 Torr; Microwave irradiation;

DOI:10.1055/s-0029-1218665

upstream raw materials:

5-(trimethylsilyl)-1-(trityloxy)pent-4-yn-2-ol

3-(methylsulfonyl)-5-phenyl-1,2,4-triazine

Downstream raw materials:

5-phenyl-3-[1-(trityloxymethyl)but-3-ynyloxy]-1,2,4-triazine

6-phenyl-4-(trimethylsilyl)-2-(trityloxymethyl)-2,3-dihydrofuro[2,3-b]pyridine

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