Technology Process of (+)-(S)-3-(4-chlorophenyl)-3-phenylpropan-1-ol
There total 5 articles about (+)-(S)-3-(4-chlorophenyl)-3-phenylpropan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(-)-(S)-1-chloro-4-(1-phenylallyl)benzene;
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.16667h;
Schlenk technique;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
water;
at 0 - 20 ℃;
for 1h;
DOI:10.1021/acs.orglett.5b03396
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: C45H42ClCuN2 / dichloromethane; dibutyl ether; hexane / 2 h / -80 °C / Inert atmosphere; Schlenk technique
2.1: borane-THF / tetrahydrofuran / 1.17 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
2.2: 1 h / 0 - 20 °C
With
borane-THF; C45H42ClCuN2;
In
tetrahydrofuran; hexane; dichloromethane; dibutyl ether;
DOI:10.1021/acs.orglett.5b03396
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Inert atmosphere; Schlenk technique
1.2: Inert atmosphere; Schlenk technique
2.1: C45H42ClCuN2 / dichloromethane; dibutyl ether; hexane / 2 h / -80 °C / Inert atmosphere; Schlenk technique
3.1: borane-THF / tetrahydrofuran / 1.17 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.2: 1 h / 0 - 20 °C
With
borane-THF; C45H42ClCuN2;
In
tetrahydrofuran; hexane; dichloromethane; dibutyl ether;
DOI:10.1021/acs.orglett.5b03396
