5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

Base Information

Chemical Name:5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine
CAS No.:1451735-27-5
Molecular Formula:C₂₀H₂₂N₆
Molecular Weight:346.435
Hs Code.:

Synonyms:5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

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Chemical Property of 5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

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Technology Process of 5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

There total 3 articles about 5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451735-35-5
5,8-dimethyl-2-[(E)-1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl][1,2,4]triazolo[1,5a]pyrazine

: 1451735-27-5
5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; dichloromethane; under 750.075 - 2250.23 Torr;

Reference yield:

: 1447715-66-3
2-(1-chloroethyl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

: 1451735-27-5
5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 4 h / 200 °C / Microwave irradiation

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 48 h / 20 °C

3: hydrogen; acetic acid; palladium 10% on activated carbon / dichloromethane; methanol / 750.08 - 2250.23 Torr

With palladium 10% on activated carbon; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethanol; dichloromethane; acetonitrile; 2: |Wittig Olefination;

Reference yield:

: 13134-38-8
3,6-dimethylpyrazin-2-yl amine

: 1451735-27-5
5,8-dimethyl-2-[1-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: mesitylenesulfonylhydroxylamine / dichloromethane / 0.25 h / 20 °C / Cooling with ice

1.2: 0.08 h / 20 °C

1.3: 48 h / 20 °C

2.1: acetonitrile / 4 h / 200 °C / Microwave irradiation

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 48 h / 20 °C

4.1: hydrogen; acetic acid; palladium 10% on activated carbon / dichloromethane; methanol / 750.08 - 2250.23 Torr

With palladium 10% on activated carbon; hydrogen; mesitylenesulfonylhydroxylamine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethanol; dichloromethane; acetonitrile; 3.1: |Wittig Olefination;