(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Base Information

Chemical Name:(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:51762-40-4
Molecular Formula:C₁₆H₁₆N₂O₆S
Molecular Weight:364.379
Hs Code.:

(6<i>R</i>)-7<i>t</i>-((<i>R</i>)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6<i>r</i><i>H</i>)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Synonyms:(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Property of (6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Technology Process of (6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 4 articles about (6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53116-61-3
(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 51762-40-4
(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00238a017

Reference yield:

: 53116-52-2
(6R)-7t-amino-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 51762-40-4
(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHSO₃ / ethyl acetate

2: H₂ / Pd-C / tetrahydrofuran; methanol

With hydrogen; sodium hydrogensulfite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm00238a017

Reference yield:

: 53116-43-1
(6R)-7t-amino-3,8-dioxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 4-nitro-benzyl ester; hydrochloride

: 51762-40-4
(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / diethyl ether; tetrahydrofuran

2: aq. NaHSO₃ / ethyl acetate

3: H₂ / Pd-C / tetrahydrofuran; methanol

With hydrogen; sodium hydrogensulfite; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate;
DOI:10.1021/jm00238a017