epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine

Base Information

• Chemical Name: epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine
• CAS No.: 1159108-08-3
• Molecular Formula: C₃₃H₅₂N₁₈O₉S
• Molecular Weight: 876.957
• Mol file: 1159108-08-3.mol

Synonyms:epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine

Chemical Property of epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine

There total 1 articles about epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

epi-5-N[[[αN-(9-fluorenylmethyloxycarbonyl)-γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine (1159108-05-0) → epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine (1159108-08-3)

Guidance literature:

With diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2009.03.021

Reference yield: 78.0%

epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine (1159108-08-3) + 3'-O-Acetyl-5'-oxothymidine (202722-92-7) → C45H64N20O15S (1174010-35-5)

Guidance literature:

3'-O-Acetyl-5'-oxothymidine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tet.2009.04.084

Reference yield: 76.0%

epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine (1159108-08-3) + 2',3'-di-O-acetyluridine-5'-carboxylic acid (148116-17-0) → C46H64N20O17S (1174010-36-6)

Guidance literature:

2',3'-di-O-acetyluridine-5'-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

epi-5-N[[[γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tet.2009.04.084

upstream raw materials:

epi-5-N[[[αN-(9-fluorenylmethyloxycarbonyl)-γN-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]arginyl]aminoethyl]-1,3,2',6'-tetraazido neamine

Downstream raw materials:

C₄₆H₆₅N₂₃O₁₃S

C₄₅H₆₅N₂₁O₁₄S

C₄₆H₆₄N₂₀O₁₇S

C₄₅H₆₄N₂₀O₁₅S