ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate
• CAS No.: 219325-58-3
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 219325-58-3.mol

Synonyms:ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate

Chemical Property of ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate

There total 2 articles about ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

ethyl 5-methoxy-1-methyl-4-nitro-2-phenylindole-3-carboxylate (219325-57-2) → ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate (219325-58-3)

Guidance literature:

With hydrogenchloride; tin; In ethanol; for 2h; Heating;

DOI:10.1021/jm980328r

Reference yield:

ethyl 5-methoxy-1-methyl-2-phenyl-1H-indole-3-carboxylate (219325-56-1) → ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate (219325-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / HNO₃, AcOH / 2 h / Ambient temperature

2: 59 percent / Sn, 3M aq. HCl / ethanol / 2 h / Heating

With hydrogenchloride; tin; nitric acid; acetic acid; In ethanol;

DOI:10.1021/jm980328r

Reference yield: 96.0%

ethyl 4-amino-5-methoxy-1-methyl-2-phenylindole-3-carboxylate (219325-58-3) → 5-methoxy-1-methyl-4,7-dioxo-2-phenyl-4,7-dihydro-1H-indole-3-carboxylic acid ethyl ester

Guidance literature:

With potassium nitrososulfonate; dihydrogen phosphate buffer; In acetone; for 3h; Ambient temperature;

DOI:10.1021/jm980328r

upstream raw materials:

ethyl 5-methoxy-1-methyl-4-nitro-2-phenylindole-3-carboxylate

ethyl 5-methoxy-1-methyl-2-phenyl-1H-indole-3-carboxylate