tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate
CAS No.:1105712-02-4
Molecular Formula:C₂₇H₂₇F₃N₄O₃
Molecular Weight:512.532
Hs Code.:

Synonyms:tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

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Chemical Property of tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

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Technology Process of tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

There total 2 articles about tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1105709-93-0
N'-hydroxyisoquinoline-6-carboxamidine

: 1104071-21-7
(R)-4-(tertbutoxycarbonylamino)-5-(4-(trifluoromethyl)phenyl)pentanoic acid

: 1105712-02-4
tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1016/j.bmcl.2010.01.067

Reference yield:

: 1105709-93-0
N'-hydroxyisoquinoline-6-carboxamidine

: C₂₀H₂₄F₃N₃O₃

: 1105712-02-4
tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 3.08333h; Sonication;

Reference yield:

: 1105712-02-4
tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

: 1105709-25-8
(2R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-amine

Guidance literature:: tert-butyl (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonia; In methanol;