2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

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Chemical Name:2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid
CAS No.:1415673-48-1
Molecular Formula:C₄₁H₃₄F₃N₅O₅
Molecular Weight:733.747
Hs Code.:

Synonyms:2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

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Chemical Property of 2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

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Technology Process of 2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

There total 3 articles about 2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1415675-38-5
4'-methyl-[1,1'-biphenyl]-4-carbohydrazonamide

: 1415675-35-2
4-((N-(2-(tert-butoxy)-2-oxoethyl)-4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)benzamido)methyl)benzoic acid

: 1415673-48-1
2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

Guidance literature:: 4-((N-(2-(tert-butoxy)-2-oxoethyl)-4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)benzamido)methyl)benzoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In 1,4-dioxane; at 20 ℃; for 1h;

4'-methyl-[1,1'-biphenyl]-4-carbohydrazonamide; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 - 120 ℃; for 1.5h;

Reference yield:

: 50670-50-3
p-(p-tolyl)benzonitrile

: 1415673-48-1
2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine; n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,4-dioxane / 1 h / 20 °C

2.2: 1.5 h / 20 - 120 °C

With 4-methyl-morpholine; n-butyllithium; hydrazine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; hexane;

Reference yield:

: 1415675-34-1
tert-butyl 2-(N-(4-iodobenzyl)-4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)benzamido)acetate

: 1415673-48-1
2-(4-(2-(4-methoxy-2-(trifluoromethyl)phenyl)acetamido)-N-(4-(5-(4'-methyl-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)benzyl)benzamido)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; lithium formate / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h / 110 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,4-dioxane / 1 h / 20 °C

2.2: 1.5 h / 20 - 120 °C

With 4-methyl-morpholine; lithium formate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In 1,4-dioxane; N,N-dimethyl-formamide;