2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene

Base Information

• Chemical Name: 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene
• CAS No.: 1245574-87-1
• Molecular Formula: C₅₃H₈₀BrFO₂
• Molecular Weight: 848.119
• Mol file: 1245574-87-1.mol

Synonyms:2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene

Chemical Property of 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene

There total 6 articles about 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-fluorenol (1367249-34-0) → 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene (1245574-87-1)

Guidance literature:

With Acetyl bromide; In chloroform; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2012.02.006

Reference yield:

2-(12-docosyloxydodecanoxy)-9-fluorenone (1245574-86-0) → 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene (1245574-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 50 °C / Inert atmosphere

2: Acetyl bromide / chloroform / 1 h / 20 °C

With Acetyl bromide; In tetrahydrofuran; chloroform; 1: Grignard reaction;

DOI:10.1016/j.tetlet.2012.02.006

Reference yield:

12-docosyloxy-1-bromododecane (1245574-85-9) → 2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-bromofluorene (1245574-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: tetrahydrofuran / 50 °C / Inert atmosphere

3: Acetyl bromide / chloroform / 1 h / 20 °C

With Acetyl bromide; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 2: Grignard reaction;

DOI:10.1016/j.tetlet.2012.02.006

upstream raw materials:

2-(12-docosyloxydodecanoxy)-9-(3-fluorophenyl)-9-fluorenol

12-docosyloxy-1-bromododecane

2-(12-docosyloxydodecanoxy)-9-fluorenone

2-hydroxyfluoren-9-one

Downstream raw materials:

Fmoc-Ala-O-fl

H-Ala-O-fl

Fmoc-Pro-Ala-O-fl

H-Pro-Ala-O-fl