N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide
CAS No.:1308255-55-1
Molecular Formula:C₂₀H₁₈BF₃N₄O₆S
Molecular Weight:510.258
Hs Code.:

Synonyms:N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

There total 6 articles about N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1308256-66-7
2-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride

: 117098-94-9
(5-amino-2-hydroxymethylphenyl)boronic acid

: 1308255-55-1
N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 1877-73-2
3-nitro-benzeneacetic acid

: 1308255-55-1
N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

2: acetic acid / 3 h / Reflux

3: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

4: triethylamine / dichloromethane / 16 h

5: chlorosulfonic acid / 2 h / 0 - 20 °C / Neat (no solvent)

6: pyridine / acetonitrile / 3 h / 20 °C

With pyridine; chlorosulfonic acid; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1308256-63-4
2-ethyl-5-(3-nitrobenzyl)-1,3,4-oxadiazole

: 1308255-55-1
N-(3-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2: triethylamine / dichloromethane / 16 h

3: chlorosulfonic acid / 2 h / 0 - 20 °C / Neat (no solvent)

4: pyridine / acetonitrile / 3 h / 20 °C

With pyridine; chlorosulfonic acid; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;