5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

Base Information

Chemical Name:5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid
CAS No.:1398412-09-3
Molecular Formula:C₃₂H₃₄N₄O₄
Molecular Weight:538.646
Hs Code.:

Synonyms:5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

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Chemical Property of 5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

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Technology Process of 5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

There total 9 articles about 5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₈N₄O₄

: 1398412-09-3
5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

Guidance literature:: With water; lithium hydroxide;

Reference yield:

: 51605-32-4
Ethyl 5-Methyl-4-imidazolecarboxylate

: 1398412-09-3
5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / ISOPROPYLAMIDE / 0.5 h / 150 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.67 h / 120 °C

3: caesium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5: sodium cyanoborohydride; acetic acid / methanol / 16.75 h / 20 - 50 °C

6: water; lithium hydroxide

With water; sodium cyanoborohydride; sodium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Suzuki Coupling / 3: Mitsunobu reaction;

Reference yield:

: 1398414-93-1
C₁₂H₁₂ClN₃O₂

: 1398412-09-3
5-methyl-1-[6-[3-methyl-2-[(2-tetrahydropyran-4-yl-3,4-dihydro-1H-isoquinolin-6-yl)methoxy]phenyl]-2-pyridyl]imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.67 h / 120 °C

2: caesium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

4: sodium cyanoborohydride; acetic acid / methanol / 16.75 h / 20 - 50 °C

5: water; lithium hydroxide

With water; sodium cyanoborohydride; sodium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Mitsunobu reaction;