C₁₅H₁₁F₃O₂

Base Information

• Chemical Name: C₁₅H₁₁F₃O₂
• CAS No.: 1338561-03-7
• Molecular Formula: C₁₅H₁₁F₃O₂
• Molecular Weight: 280.246
• Mol file: 1338561-03-7.mol

Synonyms:C₁₅H₁₁F₃O₂

Chemical Property of C₁₅H₁₁F₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁F₃O₂

There total 1 articles about C₁₅H₁₁F₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

o-fluorobenzyl bromide (446-48-0) + methyl 2,6-difluoro-3-iodobenzoate (501433-14-3) → C15H11F3O2 (1338561-03-7)

Guidance literature:

o-fluorobenzyl bromide; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

methyl 2,6-difluoro-3-iodobenzoate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene; at 60 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2011.07.037

Reference yield:

C15H11F3O2 (1338561-03-7) → C14H9F3O2 (1338561-04-8)

Guidance literature:

C₁₅H₁₁F₃O₂; With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2; Cooling with ice;

DOI:10.1016/j.bmc.2011.07.037

Reference yield:

C15H11F3O2 (1338561-03-7) → 6-(2-fluorobenzyl)-1-benzyl-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1338560-95-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

1.2: pH 2 / Cooling with ice

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

2.2: 60 °C

2.3: pH 6 - 7

3.1: tetrahydrofuran / 3 h / 50 °C

4.1: tetrahydrofuran / 60 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 90 °C

6.1: lithium hydroxide / 1,4-dioxane; water / 3 h / 50 °C

6.2: pH 2 / Cooling with ice

7.1: sodium hydroxide / 1,4-dioxane / 80 °C

7.2: pH 2 / Cooling with ice

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.07.037

upstream raw materials:

o-fluorobenzyl bromide

methyl 2,6-difluoro-3-iodobenzoate

Downstream raw materials:

6-(2-fluorobenzyl)-1-benzyl-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

6-(2-fluorobenzyl)-1-(2-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C₁₄H₉F₃O₂

C₁₇H₁₃F₃O₃