N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

Base Information

Chemical Name:N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide
CAS No.:137302-47-7
Molecular Formula:C₃₆H₅₄F₂N₈O₈S
Molecular Weight:796.936
Hs Code.:

N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

Synonyms:N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

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Chemical Property of N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

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Technology Process of N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

There total 9 articles about N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.8%

: 137302-84-2
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-4-[(S)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

: 137302-47-7
N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

Guidance literature:: With acetic acid; at 80 ℃; for 0.166667h;
DOI:10.1021/jm00079a001

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 137302-47-7
N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

3: HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

4: HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

5: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

6: 42.8 percent / 80percent AcOH / 0.17 h / 80 °C

With hydrogenchloride; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 137302-47-7
N-(4-morpholinylsulfonyl)-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-histidinamide

Guidance literature:: Multi-step reaction with 8 steps

1: Zn, I₂ / tetrahydrofuran / 0.5 h / Heating

2: 79 percent / NaOH / tetrahydrofuran / 4 h

3: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

4: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

5: HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

6: HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

7: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

8: 42.8 percent / 80percent AcOH / 0.17 h / 80 °C

With hydrogenchloride; sodium hydroxide; iodine; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001