N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

Base Information

Chemical Name:N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide
CAS No.:1383988-12-2
Molecular Formula:C₂₃H₂₁N₅O₄S
Molecular Weight:463.517
Hs Code.:

Synonyms:N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

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Chemical Property of N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

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Technology Process of N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

There total 3 articles about N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.1%

: 1383987-90-3
2-amino-6-(5-amino-6-methoxypyridin-3-yl)-3-phenylquinazolin-4(3H)-one

: 139631-62-2
cyclopropanesulfonyl chloride

: 1383988-12-2
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 72h;

Reference yield:

: 893440-50-1
2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine

: 1383988-12-2
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 72 h / 20 °C

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water;

Reference yield:

: 223704-97-0
2-amino-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383988-12-2
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 72 h / 20 °C

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water;