5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole, 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-4-fluorobenzene

Base Information

• Chemical Name: 5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole, 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-4-fluorobenzene
• CAS No.: 946418-98-0
• Molecular Formula: C₉H₆ClFN₂S
• Molecular Weight: 228.677
• Hs Code.: 2934999090
• Mol file: 946418-98-0.mol

Synonyms:5-chloro-3-(4-fluorobenzyl)-1,2,4-thiadiazole

Chemical Property of 5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole, 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-4-fluorobenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole, 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-4-fluorobenzene

There total 1 articles about 5-Chloro-3-[(4-fluorophenyl)methyl]-1,2,4-thiadiazole, 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

→ 5-chloro-3-(4-fluorobenzyl)-1,2,4-thiadiazole (946418-98-0)

Guidance literature:

Reference yield: 78.0%

2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (896464-16-7) + 5-chloro-3-(4-fluorobenzyl)-1,2,4-thiadiazole (946418-98-0) → tert-butyl 2-(3-(4-fluorobenzyl)-1,2,4-thiadiazol-5-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

Reference yield:

5-chloro-3-(4-fluorobenzyl)-1,2,4-thiadiazole (946418-98-0) → 3-(1-(4-fluorophenyl)ethyl)-5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-thiadiazole trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h

2.2: 23 h / 20 °C

3.1: dichloromethane / 15 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

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