tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate
CAS No.:1386982-10-0
Molecular Formula:C₂₉H₃₅ClN₆O₆
Molecular Weight:599.087
Hs Code.:

Synonyms:tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

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Chemical Property of tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

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Technology Process of tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

There total 6 articles about tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.4%

: 1270370-49-4
tert-butyl (2-amino-2-cyclohexylethyl)carbamate

: 1386980-75-1
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid

: 1386982-10-0
tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

Guidance literature:: 4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl (2-amino-2-cyclohexylethyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1386980-73-9
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid

: 1386982-10-0
tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydroxide; water / methanol / 18 h / 65 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 24 h / 20 °C

With water; triethylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1386982-11-1
tert-butyl 2-cyclohexyl-2-(1,3-dioxoisoindolin-2-yl)ethylcarbamate

: 1386982-10-0
tert-butyl 2-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-cyclohexylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine / methanol / 8 h / Reflux

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 24 h / 20 °C

With triethylamine; HATU; hydrazine; In methanol; N,N-dimethyl-formamide;