(3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Base Information

• Chemical Name: (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine
• CAS No.: 134875-81-3
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.295

Synonyms:(3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Chemical Property of (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

There total 8 articles about (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-2-phenylglycinol (56613-80-0) → (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine (134875-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / butan-1-ol / 20 h / Heating

2: aq. K₂CO₃, Na₂S₂O₄ / diethyl ether / Heating

3: alumina / pentane; CH₂Cl₂

With aluminum oxide; sodium dithionite; potassium carbonate; In diethyl ether; dichloromethane; pentane; butan-1-ol;

DOI:10.1021/jo961323+

Reference yield:

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride (6526-37-0) → (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine (134875-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / butan-1-ol / 20 h / Heating

2: aq. K₂CO₃, Na₂S₂O₄ / diethyl ether / Heating

3: alumina / pentane; CH₂Cl₂

With aluminum oxide; sodium dithionite; potassium carbonate; In diethyl ether; dichloromethane; pentane; butan-1-ol;

DOI:10.1021/jo961323+

Reference yield:

1-((R)-2-Hydroxy-1-phenyl-ethyl)-3-methyl-pyridinium; chloride (135124-73-1) → (3R,8aS)-6-Methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine (134875-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. K₂CO₃, Na₂S₂O₄ / diethyl ether / Heating

2: alumina / pentane; CH₂Cl₂

With aluminum oxide; sodium dithionite; potassium carbonate; In diethyl ether; dichloromethane; pentane;

DOI:10.1021/jo961323+

upstream raw materials:

(2R)-(-)-2-(3-methyl-4H-pyridin-1-yl)-2-phenylethanol

D-2-phenylglycinol

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride

1-((R)-2-Hydroxy-1-phenyl-ethyl)-3-methyl-pyridinium; chloride

Downstream raw materials:

(2S,3R,6R)-(+)-2,6-diisopropyl-3-methyl-1-[(1R)-1-phenyl-2-hydroxyethyl]piperidine

(3R,5S)-5-Isopropyl-8-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine

(R)-2-[(2S,3S,6S)-2-(2-[1,3]Dioxolan-2-yl-ethyl)-3-methyl-6-pentyl-piperidin-1-yl]-2-phenyl-ethanol

(R)-2-[(2S,3R,6R)-2-(2-[1,3]Dioxolan-2-yl-ethyl)-3-methyl-6-pentyl-piperidin-1-yl]-2-phenyl-ethanol

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