(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol
CAS No.:1054618-28-8
Molecular Formula:C₂₄H₂₅N₇O₂
Molecular Weight:443.508
Hs Code.:

Synonyms:(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

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Chemical Property of (2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

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Technology Process of (2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

There total 6 articles about (2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: Acetic acid (2R,3R,5S)-2-(6-acetylamino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-yl ester

: 1054618-28-8
(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

Guidance literature:: With ammonia; In methanol; at 0 ℃; for 14h;
DOI:10.1021/jm960828p

Reference yield:

: 73-03-0
cordycepin

: 1054618-28-8
(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 24 h / Ambient temperature

2: 27 percent / pyridine / 7 h / 3 °C

3: 71 percent / TBAF / tetrahydrofuran / 2 h / 5 °C

4: DMSO, DCC, Cl₂CHCOOH

5: 1.) RT, 1 h, 2.) 5 deg C, 15 h

6: 44 percent / NH₃ / methanol / 14 h / 0 °C

With pyridine; dichloro-acetic acid; tetrabutyl ammonium fluoride; ammonia; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm960828p

Reference yield:

: Acetic acid (2R,3R,5S)-2-(6-acetylamino-purin-9-yl)-5-formyl-tetrahydro-furan-3-yl ester

: 1054618-28-8
(2R,3R,5S)-2-(6-Amino-purin-9-yl)-5-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) RT, 1 h, 2.) 5 deg C, 15 h

2: 44 percent / NH₃ / methanol / 14 h / 0 °C

With ammonia; In methanol;
DOI:10.1021/jm960828p