Technology Process of 3-(2-(2,6,6-trimethylcyclohex-1-enyl)ethyl)furan
There total 6 articles about 3-(2-(2,6,6-trimethylcyclohex-1-enyl)ethyl)furan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
{[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl}benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -60 ℃;
for 0.25h;
Inert atmosphere;
3-(chloromethyl)furan;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 2h;
Inert atmosphere;
With
diethylamine; naphthalen-1-yl-lithium;
In
tetrahydrofuran;
at -75 ℃;
for 1h;
Inert atmosphere;
DOI:10.3390/md17040245
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate / methanol
2.1: pyridine; dmap / dichloromethane / 4 h
3.1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C
4.1: dihydrogen peroxide; ammonium molibdate / methanol / 8 h / 0 - 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -60 °C / Inert atmosphere
5.2: 2 h / 20 °C / Inert atmosphere
5.3: 1 h / -75 °C / Inert atmosphere
With
pyridine; dmap; ammonium molibdate; sodium tetrahydroborate; n-butyllithium; dihydrogen peroxide; potassium carbonate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.3390/md17040245
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine; dmap / dichloromethane / 4 h
2.1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C
3.1: dihydrogen peroxide; ammonium molibdate / methanol / 8 h / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -60 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
4.3: 1 h / -75 °C / Inert atmosphere
With
pyridine; dmap; ammonium molibdate; n-butyllithium; dihydrogen peroxide; potassium carbonate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.3390/md17040245
