(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Base Information

Chemical Name:(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine
CAS No.:188950-16-5
Molecular Formula:C₃₁H₃₁N₃O₃
Molecular Weight:493.605
Hs Code.:

(+/-)-N<sup>4</sup>-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Synonyms:(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Chemical Property:

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Technology Process of (+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

There total 3 articles about (+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 188949-75-9
(+/-)-N⁴-(monomethoxytrityl)-1-[4-(ethoxycarbonyl)-3-cyclohexenyl]cytosine

: 188950-16-5
(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 ℃; for 0.666667h;
DOI:10.1021/jo962204x

Reference yield:

: 172405-52-6
N⁴-[(4-methoxyphenyl)diphenylmethyl]cytosine

: 188950-16-5
(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) DBU / 1) DMF, rt, 30 min; 2) DMF, 75 deg C, 48 h

2: 55 percent / DIBAL / CH₂Cl₂; hexane / 0.67 h / 0 °C

With N,O-bis-(trimethylsilyl)-acetamide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In hexane; dichloromethane;
DOI:10.1021/jo962204x

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 188950-16-5
(+/-)-N⁴-(monomethoxytrityl)-1-[4-(hydroxymethyl)-3-cyclohexenyl]cytosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N,O-bis(trimethylsilyl)acetamide, pyridine, 2.) DMAP / 1) rt, 2 h; 2) rt, 16 h

2: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) DBU / 1) DMF, rt, 30 min; 2) DMF, 75 deg C, 48 h

3: 55 percent / DIBAL / CH₂Cl₂; hexane / 0.67 h / 0 °C

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In hexane; dichloromethane;
DOI:10.1021/jo962204x