(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

Base Information

Chemical Name:(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine
CAS No.:128781-46-4
Molecular Formula:C₁₈H₂₈N₂O₃Si₂
Molecular Weight:376.603
Hs Code.:

Synonyms:(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

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Chemical Property of (S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

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Technology Process of (S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

There total 2 articles about (S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 13528-93-3
1,2-bis-(chlorodimethylsilyl)ethane

: 114992-58-4
(S)-5-(aminomethyl)-3-(4-acetylphenyl)-2-oxooxazolidine

: 128781-46-4
(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00171a035

Reference yield:

: 104421-21-8
N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

: 128781-46-4
(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 1 N HCl / 3 h / Heating

2: 67 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00171a035

Reference yield:

: 128781-46-4
(S)-5-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-3-(4-acetylphenyl)-2-oxooxazolidine

: (S)-5-Aminomethyl-3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / tetrahydrofuran; diethyl ether / 1.) 0-5 deg C, 30 min, 2.) RT, 2.5 h

2: NaBH₄, ethanol / 6 h / Heating

With sodium tetrahydroborate; ethanol; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00171a035