Technology Process of (2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
There total 1 articles about (2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 48 h / 125 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -65 °C
2.2: 1 h / -65 °C
2.3: 3 h / 0 - 25 °C
3.1: potassium carbonate; tert.-butylhydroperoxide / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: acetic acid; sodium tetrahydroborate; diphenyl diselenide / ethanol / 0.5 h / 25 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C
6.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 2585.81 Torr
With
tert.-butylhydroperoxide; sodium tetrahydroborate; dimethylsulfide borane complex; diphenyl diselenide; palladium on activated charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
for 2h;