(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole
CAS No.:904887-88-3
Molecular Formula:C₃₀H₂₈NO₂P
Molecular Weight:465.532
Hs Code.:

Synonyms:(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

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Chemical Property of (S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

Chemical Property:

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Technology Process of (S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

There total 9 articles about (S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 904887-85-0
(S)-2'-(diphenylphosphoryl)-N-(1-hydroxy-3-methylbutan-2-yl)biphenyl-2-carboxamide

: 904887-88-3
(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: With methanesulfonyl chloride; triethylamine;
DOI:10.1055/s-2006-933100

Reference yield:

: 155566-49-7
(+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

: 904887-88-3
(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / dppb; i-Pr₂EtN / Pd(OAc)2 / 760 Torr

2: 79 percent / NaH

3: 93 percent / methanesulfonyl chloride; Et₃N

With sodium hydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate;
DOI:10.1055/s-2006-933100

Reference yield:

: 90-43-7,287950-96-3
2-Phenylphenol

: 904887-88-3
(S)-2-(2'-(diphenylphosphoryl)biphenyl-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus trichloride / 5 h / 140 °C / Inert atmosphere; Neat (no solvent)

1.2: 3 h / 210 °C / Inert atmosphere; Neat (no solvent)

2.1: iodine; magnesium / 2 h / 50 °C / Inert atmosphere; Reflux

2.2: 25 °C / Inert atmosphere; Reflux

2.3: 0 °C / Inert atmosphere

3.1: dihydrogen peroxide / dichloromethane; water / 0 - 20 °C

4.1: pyridine; dmap / dichloromethane / 0 °C / Reflux

5.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 110 °C

6.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; iodine; palladium diacetate; magnesium; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.1007/s11426-010-4172-z