2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

Base Information

Chemical Name:2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol
CAS No.:132413-88-8
Molecular Formula:C₃₄H₄₁N₅O₄
Molecular Weight:583.731
Hs Code.:

Synonyms:2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

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Chemical Property of 2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

Chemical Property:

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Technology Process of 2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

There total 4 articles about 2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 132413-79-7
2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionic Acid

: 132413-82-2
L-Histidyl-L-leucinol di-p-toluenesulfonic Acid

: 132413-88-8
2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1248/cpb.38.3042

Reference yield:

: 66-77-3
1-naphthaldehyde

: 132413-88-8
2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

Guidance literature:: Multi-step reaction with 6 steps

1: 85.9 percent / piperidine, acetic acid / benzene / 3 h / Heating

2: 100 percent / hydrogen / 10percent Pd/C / benzene / 760 Torr

3: 38.8 percent / hydrogen, 2 N HCl / PtO₂ / ethanol / 760 Torr

4: 67.1 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 94.4 percent / 1 N NaOH / ethanol / Ambient temperature

6: 36 percent / Et₃N, diphenylphosphoryl azide / dimethylformamide / 0 °C

With piperidine; hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.38.3042

Reference yield:

: 132413-83-3
ethyl 2-(1-naphthylmethyl)-3-(phenylacetylamino)propionate

: 132413-88-8
2-(1-Naphthylmethyl)-3-(phenylacetylamino)propionyl-L-histidyl-L-leucinol

Guidance literature:: Multi-step reaction with 2 steps

1: 94.4 percent / 1 N NaOH / ethanol / Ambient temperature

2: 36 percent / Et₃N, diphenylphosphoryl azide / dimethylformamide / 0 °C

With sodium hydroxide; diphenylphosphoranyl azide; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.3042