(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

Base Information

Chemical Name:(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride
CAS No.:1542268-04-1
Molecular Formula:C₂₀H₂₃N₇O₃S*ClH
Molecular Weight:477.975
Hs Code.:

Synonyms:(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

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Chemical Property of (S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

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Technology Process of (S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

There total 12 articles about (S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1542268-03-0
C₂₅H₃₁N₇O₅S

: 1542268-04-1
(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

: 1542268-02-9
C₂₇H₂₈N₆O₆S₂

: 1542268-04-1
(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 90 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;

Reference yield:

: 2345-34-8
4-acetyloxy-benzoic acid

: 1542268-04-1
(S)-4-((4-(2-aminothiazol-5-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

3.1: potassium carbonate / methanol / 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 4 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 90 °C / Microwave irradiation

8.1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;