N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide
• CAS No.: 143371-31-7
• Molecular Formula: C₆₃H₈₃NO₈SSi₂
• Molecular Weight: 1070.59

Synonyms:N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Chemical Property of N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

There total 27 articles about N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(S)-3-[(4-Methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl}-triphenyl-phosphonium; iodide (124944-47-4) → N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide (143371-31-7)

Guidance literature:

Multi-step reaction with 11 steps

1: n-butyllithium, LiBr / tetrahydrofuran / 0.75 h / 0 °C

2: 2.) phenyllithium, 3.) t-BuOK

3: 95 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

4: 81 percent / pyridine / 48 h / Ambient temperature

5: 97 percent / NaH, 18-crown-6 / tetrahydrofuran / 3 h

6: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min

7: 95 percent / imidazole, 4-pyrrolidinopyridine / dimethylformamide / 18 h

8: 88 percent / HgO, BF₃*Et₂O / tetrahydrofuran; H₂O / 5 h

9: 1.) lithium diisopropylamide (LDA) / 1.) THF, hexane, -78 deg C, 90 min, 2.) THF, hexane, -78 deg C, 40 min

10: 63 percent / (COCl)2, Me₂SO / CH₂Cl₂ / 0.25 h

11: 43 percent / diethyl ether / 0.25 h / Ambient temperature

With pyridine; 1H-imidazole; n-butyllithium; oxalyl dichloride; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium tert-butylate; water; sodium hydride; 4-pyrrolidin-1-ylpyridine; acetic acid; dimethyl sulfoxide; phenyllithium; mercury(II) oxide; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00047a008

Reference yield:

N-(4-Methoxy-benzyl)-4-methyl-N-[(S)-1-phenyl-3-(triphenyl-λ5-phosphanylidene)-propyl]-benzenesulfonamide → N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide (143371-31-7)

Guidance literature:

Multi-step reaction with 10 steps

1: 2.) phenyllithium, 3.) t-BuOK

2: 95 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

3: 81 percent / pyridine / 48 h / Ambient temperature

4: 97 percent / NaH, 18-crown-6 / tetrahydrofuran / 3 h

5: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min

6: 95 percent / imidazole, 4-pyrrolidinopyridine / dimethylformamide / 18 h

7: 88 percent / HgO, BF₃*Et₂O / tetrahydrofuran; H₂O / 5 h

8: 1.) lithium diisopropylamide (LDA) / 1.) THF, hexane, -78 deg C, 90 min, 2.) THF, hexane, -78 deg C, 40 min

9: 63 percent / (COCl)2, Me₂SO / CH₂Cl₂ / 0.25 h

10: 43 percent / diethyl ether / 0.25 h / Ambient temperature

With pyridine; 1H-imidazole; n-butyllithium; oxalyl dichloride; 18-crown-6 ether; boron trifluoride diethyl etherate; potassium tert-butylate; water; sodium hydride; 4-pyrrolidin-1-ylpyridine; acetic acid; dimethyl sulfoxide; phenyllithium; mercury(II) oxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00047a008

Reference yield:

(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone (52813-63-5) → N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide (143371-31-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 100 percent / CBr₄, PPh₃ / tetrahydrofuran / 2 h

2: diisobutylaluminum hydride (DIBAL) / CH₂Cl₂; hexane / 0.5 h / -78 °C

3: 1.) lithium diisopropylamide (LDA) / 1.) THF, 0 deg C, 10 min, 2.) THF, hexane, 0 deg C, 1 h

4: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min

5: 95 percent / imidazole, 4-pyrrolidinopyridine / dimethylformamide / 18 h

6: 88 percent / HgO, BF₃*Et₂O / tetrahydrofuran; H₂O / 5 h

7: 1.) lithium diisopropylamide (LDA) / 1.) THF, hexane, -78 deg C, 90 min, 2.) THF, hexane, -78 deg C, 40 min

8: 63 percent / (COCl)2, Me₂SO / CH₂Cl₂ / 0.25 h

9: 43 percent / diethyl ether / 0.25 h / Ambient temperature

With 1H-imidazole; n-butyllithium; oxalyl dichloride; carbon tetrabromide; boron trifluoride diethyl etherate; diisobutylaluminium hydride; 4-pyrrolidin-1-ylpyridine; dimethyl sulfoxide; triphenylphosphine; mercury(II) oxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00047a008

upstream raw materials:

diazomethane

N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-3-methoxy-2-oxo-cyclopentyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone

maleic anhydride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143371-31-7 N-[(Z)-(1S,7S)-9-{(3S,5R)-5-[(Z)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-2,3-dimethoxy-cyclopent-1-enyl}-7-(tert-butyl-diphenyl-silanyloxy)-9-oxo-1-phenyl-non-3-enyl]-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send