4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Base Information

• Chemical Name: 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran
• CAS No.: 120034-16-4
• Molecular Formula: C₁₇H₁₅ClO₃
• Molecular Weight: 302.757
• Mol file: 120034-16-4.mol

Synonyms:4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Chemical Property of 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

There total 5 articles about 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-hydroxy-7-chloro-5-tert-butyl-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-13-1) → 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-16-4)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm00126a008

Reference yield:

3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone (120034-10-8) → 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-16-4)

Guidance literature:

Multi-step reaction with 3 steps

2: 81 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

With aluminium trichloride; sodium cyanoborohydride; zinc(II) iodide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00126a008

Reference yield:

(5-tert-Butyl-7-chloro-4-hydroxy-3-methyl-benzofuran-2-yl)-(4-methoxy-phenyl)-methanone → 4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

2: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

With aluminium trichloride; sodium cyanoborohydride; zinc(II) iodide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00126a008

upstream raw materials:

4-hydroxy-7-chloro-5-tert-butyl-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

5-allyl-4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

4-(allyloxy)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propionic acid

3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol