2,3-Dihydroxy-2-methylbutanoic acid

Base Information

• Chemical Name: 2,3-Dihydroxy-2-methylbutanoic acid
• CAS No.: 14868-24-7
• Molecular Formula: C5H10 O4
• Molecular Weight: 134.132
• NSC Number: 181497
• DSSTox Substance ID: DTXSID20306894
• Nikkaji Number: J1.058.325J
• Metabolomics Workbench ID: 43917
• Mol file: 14868-24-7.mol

Synonyms:2,3-dihydroxy-2-methylbutanoic acid;14868-24-7;NSC181497;2,3-Dimethylglyceric acid;SCHEMBL183284;DTXSID20306894;CHEBI:173559;2,3-dihydroxy-2-methylbutanoicacid;2,3-Dihydroxy-2-methylbutyric acid;2-methyl-2,3-dihydroxybutyric acid;LMFA01050468;AKOS006376264;NSC 181497;NSC-181497;EN300-202922;Z1205494313

Chemical Property of 2,3-Dihydroxy-2-methylbutanoic acid

Chemical Property:

• Vapor Pressure: 1.07E-05mmHg at 25°C
• Boiling Point: 332.2°Cat760mmHg
• Flash Point: 168.9°C
• Density: 1.326g/cm³
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 134.05790880
• Heavy Atom Count: 9
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C)(C(=O)O)O)O

Technology Process of 2,3-Dihydroxy-2-methylbutanoic acid

There total 12 articles about 2,3-Dihydroxy-2-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tiglic acid (80-59-1) → 2,3-dihydroxy-2-methylbutyric acid (14868-24-7)

Guidance literature:

With potassium permanganate; water; potassium carbonate; at 0 ℃; tiglicerinic acid;

Reference yield:

Angelic acid (565-63-9) → 2,3-dihydroxy-2-methylbutyric acid (14868-24-7)

Guidance literature:

With potassium permanganate; water; potassium carbonate; at 0 ℃; aneglyceric acid;

Reference yield:

isohelmanticine → Angelic acid (565-63-9) + 2,3-dihydroxy-2-methylbutyric acid (14868-24-7) + 2-epideacyllaserine (deacylhelmanticine) (98757-06-3)

Guidance literature:

With Alkaline;

DOI:10.1016/S0031-9422(00)83124-6

upstream raw materials:

Tiglic acid

Angelic acid

methyl (E)-2-methyl-2-butenoate

Downstream raw materials:

butanone

Refernces

• 1、 Powell et al.. "". . p. 265,266, 267. Retrieved 1972.
• 2、 Teresa, J. De Pascual,Moran, Joaquin R.,Hernandez, Jose M.,Grande, M.. "PHENYLPROPANOIDS AND OTHER DERIVATIVES FROM THAPSIA VILLOSA". . p. 2071 - 2074. Retrieved 1985.
• 3、 Kaneko,Sakamoto,Ohtani,Ito,Kasai,Yamasaki,Padorina. "Secoiridoid and flavonoid glycosides from Gonocaryum calleryanum". . p. 115 - 120. Retrieved 2007/10/02.
• 4、 Robins,Crout. "Pyrrolizidine alkaloids. The absolute configuration at C-2 in monocrotalic acid.". . p. 1334 - 1336. Retrieved 2007/10/07.