1H-BENZIMIDAZOLE, 4-FLUORO-

Base Information

• Chemical Name: 1H-BENZIMIDAZOLE, 4-FLUORO-
• CAS No.: 5847-89-2
• Molecular Formula: C7H5 F N2
• Molecular Weight: 136.1264032
• Hs Code.: 2933990090
• Mol file: 5847-89-2.mol

Synonyms:1H-Benzimidazole,4-fluoro- (9CI); Benzimidazole, 4(or 7)-fluoro- (6CI,7CI); Benzimidazole,4-fluoro- (8CI); NSC 402991

Chemical Property of 1H-BENZIMIDAZOLE, 4-FLUORO-

Chemical Property:

• Vapor Pressure: 2.34E-07mmHg at 25°C
• Melting Point: 180-185 °C
• Boiling Point: 363.8°Cat760mmHg
• PKA: 11.69±0.30(Predicted)
• Flash Point: 173.8°C
• PSA: 28.68000
• Density: 1.37g/cm³
• LogP: 1.70200

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-BENZIMIDAZOLE, 4-FLUORO-

There total 5 articles about 1H-BENZIMIDAZOLE, 4-FLUORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 7-fluoro-1H-benzo[d]imidazole (5847-89-2)

Guidance literature:

With caesium carbonate; In water; at 50 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

4-fluoro-2-methylbenzimidazole (18645-89-1) → 1-amino-4-fluoro-2-methylbenzimidazole (869663-12-7) + 4-fluoro-1H-benzimidazole (5847-89-2) + 7-fluoro-1H-benzo[d]imidazole (5847-89-2)

Guidance literature:

With potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; water; at 0 - 20 ℃; for 18h;

Reference yield:

4-fluoro-2-methylbenzimidazole (18645-89-1) → 1-amino-4-fluoro-2-methylbenzimidazole (869663-12-7) + 4-fluoro-1H-benzimidazole (5847-89-2) + 7-fluoro-1H-benzo[d]imidazole (5847-89-2)

Guidance literature:

With potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; water; at 0 - 20 ℃; for 18h;

upstream raw materials:

4-fluoro-2-methylbenzimidazole

Downstream raw materials:

2-O-[(tert-butyl)dimethylsilyl]-1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(4-fluoro-1H-benzimidazol-1-yl)-β-D-ribofuranose

1-deoxy-5-O-(4,4'-dimethoxytrityl)-1-(4-fluoro-1H-benzimidazol-1-yl)-β-D-ribofuranose

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