ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Base Information

Chemical Name:ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate
CAS No.:165900-66-3
Molecular Formula:C₁₈H₂₂N₆O₃
Molecular Weight:370.411
Hs Code.:

ethyl 4-<N-<2-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Synonyms:ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

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Chemical Property of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

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Technology Process of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

There total 4 articles about ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10541-82-9
ethyl 4-(methylamino)benzoate

: 165900-66-3
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 13 h / 80 °C

2: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

3: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

4: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

5: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen; iodine; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256

Reference yield:

: 165900-79-8
methyl 4-crotonate

: 165900-66-3
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

2: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

3: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

4: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

With hydrogen; iodine; sodium ethanolate; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256

Reference yield:

: 133719-37-6
methyl 4-butyrate

: 165900-66-3
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

2: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

3: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

With iodine; sodium ethanolate; sodium hydride; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256