(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Base Information

Chemical Name:(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide
CAS No.:228863-42-1
Molecular Formula:C₁₉H₂₇NO₄Si
Molecular Weight:361.513
Hs Code.:

Synonyms:(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Suppliers and Price of (2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

There total 10 articles about (2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 588-72-7,1340-14-3
[(E)-2-bromoethenyl]benzene

: 228863-41-0
(2S,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-oxirane-2,2-dicarboxylic acid amide methoxy-methyl-amide

: 228863-42-1
(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0957-4166(99)00041-5

Reference yield:

: 110840-39-6
(S)-(+)-2-(benzyloxy)-3-methylbutanal

: 228863-42-1
(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 10 steps

1: ZnCl₂ / tetrahydrofuran / -78 °C

2: 70 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

3: 1.) lithium hexamethyldisilazide, 2.) I₂ / 1.) THF, -46 deg C to RT, 2.) THF, -46 deg C

4: tetrabutylammonium fluoride / tetrahydrofuran / -46 - 20 °C

5: 93 percent / H₂ / Pd(OH)2 / methanol / 50 °C

6: HCOOH / Ambient temperature

7: (1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, i-Pr₂EtN / CH₂Cl₂ / 0 °C

8: NH₃ / methanol / Ambient temperature

9: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

10: 80 percent / t-BuLi / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; formic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; iodine; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(99)00041-5

Reference yield:

: 228863-36-3
(S)-3-((S)-1-Benzyloxy-2-methyl-propyl)-oxirane-2,2-dicarboxylic acid di-tert-butyl ester

: 228863-42-1
(2R,3S)-3-((S)-2-Methyl-1-trimethylsilanyloxy-propyl)-2-[(E)-(3-phenyl-acryloyl)]-oxirane-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / H₂ / Pd(OH)2 / methanol / 50 °C

2: HCOOH / Ambient temperature

3: (1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, i-Pr₂EtN / CH₂Cl₂ / 0 °C

4: NH₃ / methanol / Ambient temperature

5: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

6: 80 percent / t-BuLi / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; formic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(99)00041-5