4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

Base Information

Chemical Name:4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide
CAS No.:871705-76-9
Molecular Formula:C₁₃H₁₇NO₄S
Molecular Weight:283.348
Hs Code.:

Synonyms:4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

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Chemical Property of 4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

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Technology Process of 4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

There total 4 articles about 4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 148101-11-5
(E)-3-[(4R,5R)-5-Methyl-2-oxo-3-(toluene-4-sulfonyl)-oxazolidin-4-yl]-acrylic acid ethyl ester

: 871705-76-9
4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

Guidance literature:: (E)-3-[(4R,5R)-5-Methyl-2-oxo-3-(toluene-4-sulfonyl)-oxazolidin-4-yl]-acrylic acid ethyl ester; With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

With sodium hydroxide; In methanol; water; at 20 ℃;

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2005.09.195

Reference yield:

: 2396-84-1
(2E,4E)-ethyl hexa-2,4-dienoate

: 871705-76-9
4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / AD-mix-β; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C

2.1: 86 percent / Pd(PPh₃)4 / tetrahydrofuran / Heating

3.1: H₂ / Pd/C / ethyl acetate / 20 °C

3.2: NaOH / H₂O; methanol / 20 °C

3.3: 72 percent / CF₃COOH / tetrahydrofuran / 20 °C

With methanesulfonamide; AD-mix-β; hydrogen; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; ethyl acetate; tert-butyl alcohol; 1.1: Sharpless dihydroxylation;
DOI:10.1016/j.tetlet.2005.09.195

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 871705-76-9
4-Methyl-N-((2R,3R)-2-methyl-6-oxo-tetrahydro-pyran-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / Pd(PPh₃)4 / tetrahydrofuran / Heating

2.1: H₂ / Pd/C / ethyl acetate / 20 °C

2.2: NaOH / H₂O; methanol / 20 °C

2.3: 72 percent / CF₃COOH / tetrahydrofuran / 20 °C

With hydrogen; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.tetlet.2005.09.195