2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

• Chemical Name: 2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
• CAS No.: 1195953-03-7
• Molecular Formula: C₂₁H₂₁F₂N₅O
• Molecular Weight: 397.427

Synonyms:2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Chemical Property of 2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 1 articles about 2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol (261959-40-4) → 2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (1195953-03-7)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.08.089

Reference yield: 56.0%

2-(2,4-difluorophenyl)-1-[(1H-indol-5-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (1195953-03-7) + trifluoroacetic anhydride (407-25-0) → 1-(5-{[(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl)methylamino]methyl}-1H-indol-3-yl)-2,2,2-trifluoroethanone (1195953-07-1)

Guidance literature:

In 1,2-dichloro-ethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2009.08.089

upstream raw materials:

1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol

Downstream raw materials:

1-(5-{[(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl)methylamino]methyl}-1H-indol-3-yl)-2,2,2-trifluoroethanone

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