(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

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Chemical Name:(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol
CAS No.:1269650-57-8
Molecular Formula:C₂₉H₃₄N₄O₂
Molecular Weight:470.615
Hs Code.:

Synonyms:(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

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Chemical Property of (R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

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Technology Process of (R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

There total 3 articles about (R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269650-59-0
tert-butyl (2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidine-1-carboxylate

: 1269650-57-8
(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 1269429-41-5
tert-butyl 5-((methylsulfonyl)oxy)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

: 1269650-57-8
(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

1.2: 0.25 h / 150 °C / Microwave irradiation

2.1: hydrogenchloride; water / 1,4-dioxane / 2 h / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1269431-03-9
tert-butyl [pyrrole-5-(1H-pyrazol-1-yl)hexahydrocyclopenta]c-2(1H)-carboxylate

: 1269650-57-8
(R)-phenyl [(2R,5S)-5-(4-{[5-(1H-pyrazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 1,4-dioxane / 2 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;