2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol

Base Information

• Chemical Name: 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol
• CAS No.: 126436-38-2
• Molecular Formula: C₁₆H₁₄ClN₅O₄
• Molecular Weight: 375.771
• Mol file: 126436-38-2.mol

Synonyms:2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol

Chemical Property of 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol

There total 5 articles about 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxyimino-1-(3-pyridyl)-2-propanone (65882-96-4) + 4-amino-3-chloro-2-methoxy-5-nitrobenzaldehyde (156601-84-2) → 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol (126436-38-2)

Guidance literature:

With ammonium acetate; In acetic acid; at 100 ℃; for 0.25h;

DOI:10.1248/cpb.42.560

Reference yield:

methyl 4-acetamido-2-methoxy-5-nitrobenzoate (4093-41-8) → 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol (126436-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 43.8 percent / LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

2: 2N aq. NaOH / tetrahydrofuran; ethyl acetate; H₂O

3: 38.6 percent / MnO₂ / ethyl acetate / 4.5 h / Heating

4: 38.9 percent / Cl₂ iodobenzene complex, pyridine / tetrahydrofuran / 1 h / Ambient temperature

5: ammonium acetate / acetic acid / 0.25 h / 100 °C

With pyridine; ammonium acetate; manganese(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; (Dichloroiodo)benzene; In tetrahydrofuran; water; acetic acid; ethyl acetate;

DOI:10.1248/cpb.42.560

Reference yield:

4-amino-2-methoxy-5-nitrobenzyl alcohol (1027093-46-4) → 2-(4-Amino-3-chloro-2-methoxy-5-nitro-phenyl)-4-methyl-5-pyridin-3-yl-imidazol-1-ol (126436-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 38.6 percent / MnO₂ / ethyl acetate / 4.5 h / Heating

2: 38.9 percent / Cl₂ iodobenzene complex, pyridine / tetrahydrofuran / 1 h / Ambient temperature

3: ammonium acetate / acetic acid / 0.25 h / 100 °C

With pyridine; ammonium acetate; manganese(IV) oxide; (Dichloroiodo)benzene; In tetrahydrofuran; acetic acid; ethyl acetate;

DOI:10.1248/cpb.42.560

upstream raw materials:

1-hydroxyimino-1-(3-pyridyl)-2-propanone

4-amino-3-chloro-2-methoxy-5-nitrobenzaldehyde

methyl 4-acetamido-2-methoxy-5-nitrobenzoate

4-amino-2-methoxy-5-nitrobenzyl alcohol

Downstream raw materials:

2-Chloro-3-methoxy-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-6-nitro-phenylamine

3-Chloro-4-methoxy-5-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-benzene-1,2-diamine