4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

Base Information

Chemical Name:4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol
CAS No.:1313732-97-6
Molecular Formula:C₂₁H₂₇N₇O₂
Molecular Weight:409.491
Hs Code.:

Synonyms:4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

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Chemical Property of 4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

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Technology Process of 4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

There total 5 articles about 4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1313732-06-7
[3-(4-methoxy-phenyl)-6-methyl-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(1-methyl-piperidin-4-ylmethyl)-amine

: 1313732-97-6
4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - -20 ℃; Inert atmosphere;

Reference yield:

: 66643-51-4
3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine

: 1313732-97-6
4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / tetrahydrofuran / Reflux

2: NCS / acetonitrile / 3 h / 50 °C

3: toluene-4-sulfonic acid; triethylamine / 1,4-dioxane / 100 °C

4: butan-1-ol / 180 - 185 °C / Microwave irradiation

5: boron tribromide / dichloromethane / -78 - -20 °C / Inert atmosphere

With potassium tert-butylate; boron tribromide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; butan-1-ol;

Reference yield:

: 66643-52-5
8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine

: 1313732-97-6
4-{6-methyl-5-[(1-methyl-piperidin-4-ylmethyl)-amino]-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-3-yl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: NCS / acetonitrile / 3 h / 50 °C

2: toluene-4-sulfonic acid; triethylamine / 1,4-dioxane / 100 °C

3: butan-1-ol / 180 - 185 °C / Microwave irradiation

4: boron tribromide / dichloromethane / -78 - -20 °C / Inert atmosphere

With boron tribromide; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile; butan-1-ol;