N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide

Base Information

Chemical Name:N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide
CAS No.:141171-77-9
Molecular Formula:C35H43 N5 O7
Molecular Weight:645.7452
Hs Code.:
Mol file:141171-77-9.mol

N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide

Synonyms:Butanediamide,N1-[3-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-pyrrolidinyl]-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-2-[[(1-naphthalenyloxy)acetyl]amino]-,[2S-[1[1R*(R*),2R*],2R*]]-; KNI 144

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Chemical Property of N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1058.8°C at 760 mmHg
Flash Point:594.1°C
Density:1.273g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide

There total 12 articles about N~1~-{(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl}-N~2~-[(naphthalen-1-yloxy)acetyl]-L-aspartamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126015-23-4
(2S,3S)-3-[[(benzyloxy)carbonyl]amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

: 141171-77-9
(S)-N-tert-butyl-3-[(2S,3S)-3-[(S)-2-(1-naphthoxyacetyl)aminosuccinamyl]amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / ethanol

2: tetrahydrofuran

3: NaOH / dioxane

4: HOBt, EDI / dimethylformamide

5: H₂ / Pd/C / ethanol

6: EDC, HOBt / dimethylformamide

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00085a020

Reference yield:

: (2S,3S)-3-((S)-2-Benzyloxycarbonylamino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyric acid methyl ester

: 141171-77-9
(S)-N-tert-butyl-3-[(2S,3S)-3-[(S)-2-(1-naphthoxyacetyl)aminosuccinamyl]amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / dioxane

2: HOBt, EDI / dimethylformamide

3: H₂ / Pd/C / ethanol

4: EDC, HOBt / dimethylformamide

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00085a020

Reference yield:

: 143978-10-3
Z-Asn-(2S,3S)-AHPBA-OH

: 141171-77-9
(S)-N-tert-butyl-3-[(2S,3S)-3-[(S)-2-(1-naphthoxyacetyl)aminosuccinamyl]amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt, EDI / dimethylformamide

2: H₂ / Pd/C / ethanol

3: EDC, HOBt / dimethylformamide

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00085a020