N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 1345822-13-0
• Molecular Formula: C₂₁H₂₃N₃O₃S₂
• Molecular Weight: 429.564
• Mol file: 1345822-13-0.mol

Synonyms:N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide

Chemical Property of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide

There total 3 articles about N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17N3OS (1345822-06-1) + p-toluenesulfonyl chloride (98-59-9) → N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide (1345822-13-0)

Guidance literature:

With triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide (1345822-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / methanol / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

3: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 8 h / 20 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

C19H25N3O3S (1345822-04-9) → N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide (1345822-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

2: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 8 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.09.025

upstream raw materials:

C₁₉H₂₅N₃O₃S

C₁₄H₁₇N₃OS

p-toluenesulfonyl chloride

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester