N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide

Base Information

• Chemical Name: N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide
• CAS No.: 139027-67-1
• Molecular Formula: C₃₆H₄₈N₄O₁₁
• Molecular Weight: 712.797

Synonyms:N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide

Chemical Property of N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide

There total 3 articles about N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

[(S)-5-(4-Acetylamino-phenylcarbamoyl)-5-amino-pentyl]-carbamic acid benzyl ester; compound with trifluoro-acetic acid (139009-84-0) + 1,2:4,5-di-O-isopropylidene-3-O-carboxymethyl-β-D-fructopyranose (139009-86-2) → N2-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N6-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide (139027-67-1)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; 1) 0-5 deg C, 1 h, 2) room temperature, 4 h;

DOI:10.1016/S0040-4020(01)80998-4

Reference yield:

1,2;4,5-di-O-isopropylidene-β-D-(-)-fructopyranose (25018-67-1) → N2-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N6-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide (139027-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, reflux, 0.5 h, 2) 0-5 deg C, 3 h, then 15 deg C, 16 h

2: 1N NaOH / 1.5 h / Heating

3: 74 percent / N-methylmorpholine, 1-hydroxybenzotriazole, 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide; CH₂Cl₂ / 1) 0-5 deg C, 1 h, 2) room temperature, 4 h

With 4-methyl-morpholine; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)80998-4

Reference yield:

1,2:4,5-di-O-isopropylidene-3-O-(ethoxycarbonyl)methyl-β-D-fructopyranose (139009-85-1) → N2-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N6-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide (139027-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1N NaOH / 1.5 h / Heating

2: 74 percent / N-methylmorpholine, 1-hydroxybenzotriazole, 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide; CH₂Cl₂ / 1) 0-5 deg C, 1 h, 2) room temperature, 4 h

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)80998-4

upstream raw materials:

[(S)-5-(4-Acetylamino-phenylcarbamoyl)-5-amino-pentyl]-carbamic acid benzyl ester; compound with trifluoro-acetic acid

1,2:4,5-di-O-isopropylidene-3-O-carboxymethyl-β-D-fructopyranose

1,2;4,5-di-O-isopropylidene-β-D-(-)-fructopyranose

1,2:4,5-di-O-isopropylidene-3-O-(ethoxycarbonyl)methyl-β-D-fructopyranose

Downstream raw materials:

N²-<(1,2-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-L-lysin-4-acetamidoanilide 4-toluenesulfonate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 139027-67-1 N²-<(1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-O-yl)acetyl>-N⁶-(benzyloxycarbonyl)-L-lysin-4-acetamidoanilide

Send

Send

Metric Ton KG G Pound L ML

Send

Send