(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester
CAS No.:138235-10-6
Molecular Formula:C₃₅H₃₇NO₅Si
Molecular Weight:579.768
Hs Code.:

Synonyms:(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

There total 1 articles about (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144452-46-0
3-(Dimethyl-phenyl-silanyl)-3-phenyl-propionyl chloride

: 138235-08-2
(Methoxycarbonyl)-N-(di-p-anisylmethyl)imine

: 138235-10-6
(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

: (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(S)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; Product distribution; Heating; other solvent;
DOI:10.1021/jo00031a044

Reference yield: 82.0%

: 138235-10-6
(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

: 138235-14-0
cis,anti-3-<1'-(Dimethylphenylsilyl)benzyl>-4-(methoxycarbonyl)azetidin-2-one

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at -10 ℃; for 3h;
DOI:10.1021/jo00031a044

Reference yield:

: 138235-10-6
(2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester

: 138235-18-4
Methyl 2(S*)-(benzoylamino)-4(R*)-hydroxy-3(S*)-(methoxycarbonyl)-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 3 h / -10 °C

2: ClSiMe₃ / 4 h / Ambient temperature

3: NEt₃ / CH₂Cl₂ / 4 h / Ambient temperature

4: HBF₄*OEt₂ / CH₂Cl₂ / 1 h / Ambient temperature

5: peracetic acid, triethylamine / acetic acid / 3 h / Ambient temperature

With peracetic acid; tetrafluoroboric acid diethyl ether; chloro-trimethyl-silane; ammonium cerium(IV) nitrate; triethylamine; In dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1021/jo00031a044