N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

Base Information

Chemical Name:N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide
CAS No.:245342-72-7
Molecular Formula:C₂₆H₃₃NO₅
Molecular Weight:439.552
Hs Code.:

Synonyms:N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

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Chemical Property of N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

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Technology Process of N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

There total 3 articles about N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 61699-62-5
diisopropyl squarate

: 245342-85-2
N-tert-butyl-3-phenyl-N-prop-2-ynylacrylamide

: 245342-72-7
N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/jo990089v

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: 245342-72-7
N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / -20 - 20 °C

2: 69 percent / LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

With 4-methyl-morpholine; lithium hexamethyldisilazane; isobutyl chloroformate; In tetrahydrofuran; hexane; dichloromethane; 1: Condensation / 2: Addition;
DOI:10.1021/jo990089v

Reference yield:

: 6943-49-3
N-(tert-butyl)prop-2-yn-1-amine

: 245342-72-7
N-tert-butyl-N-[3-(1-hydroxy-2,3-diisopropoxy-4-oxocyclobut-2-enyl)prop-2-ynyl]-3-phenylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / -20 - 20 °C

2: 69 percent / LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

With 4-methyl-morpholine; lithium hexamethyldisilazane; isobutyl chloroformate; In tetrahydrofuran; hexane; dichloromethane; 1: Condensation / 2: Addition;
DOI:10.1021/jo990089v