3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

Base Information

Chemical Name:3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine
CAS No.:420122-62-9
Molecular Formula:C₃₅H₄₄N₄O₅Si
Molecular Weight:628.844
Hs Code.:

Synonyms:3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

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Chemical Property of 3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

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Technology Process of 3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

There total 10 articles about 3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 256494-90-3
2'-O-(tert-butyldimethylsilyl)-3'-(trifluoroacetamido)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

: 420122-62-9
3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 144h;
DOI:10.1016/S0040-4020(01)01185-1

Reference yield:

: 218967-53-4
2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3-(hydroxylamino)uridine

: 420122-62-9
3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / acetic acid; H₂O / 3 h / 20 °C

2: 2.22 g / Et₃N / methanol / 12 h / 20 °C

3: pyridine / 24 h / 20 °C

4: 1.22 g / NaN₃; NH₄Cl / dimethylformamide / 1 h / 80 °C

5: H₂S / pyridine; H₂O / 5 h / 20 °C

6: 2.21 g / pyridine / 3 h / 20 °C

7: 83 percent / NH₃ / methanol / 144 h / 20 °C

With pyridine; sodium azide; hydrogen sulfide; ammonia; hydrogen; ammonium chloride; triethylamine; palladium on activated charcoal; In pyridine; methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01185-1

Reference yield:

: toluene-4-sulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2,2,2-trifluoro-acetylamino)-tetrahydro-furan-2-ylmethyl ester

: 420122-62-9
3'-amino-2'-O-(tert-butyldimethylsilyl)-5'-(4-monomethoxytritylamino)-3',5'-dideoxyuridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.22 g / NaN₃; NH₄Cl / dimethylformamide / 1 h / 80 °C

2: H₂S / pyridine; H₂O / 5 h / 20 °C

3: 2.21 g / pyridine / 3 h / 20 °C

4: 83 percent / NH₃ / methanol / 144 h / 20 °C

With pyridine; sodium azide; hydrogen sulfide; ammonia; ammonium chloride; In pyridine; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01185-1