tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

Base Information

Chemical Name:tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate
CAS No.:1566584-84-6
Molecular Formula:C₁₉H₂₂ClF₃N₄O₃
Molecular Weight:446.857
Hs Code.:

Synonyms:tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

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Chemical Property of tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

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Technology Process of tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

There total 4 articles about tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 643087-72-3
tert-butyl 4-aminobenzyl(2-hydroxyethyl)carbamate

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1566584-84-6
tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 0 ℃; for 1h; Inert atmosphere;

tert-butyl 4-aminobenzyl(2-hydroxyethyl)carbamate; With triethylamine; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 0 - 20 ℃; for 20.5h;

Reference yield:

: 64834-64-6
2-(4-nitrobenzylbenzylamino)ethanol

: 1566584-84-6
tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / dichloromethane / 18 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h

3.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 1 h / 0 °C / Inert atmosphere

3.2: 20.5 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; zinc(II) chloride; In diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1566584-84-6
tert-butyl 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl(2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

2.1: sodium hydroxide / dichloromethane / 18 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h

4.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 1 h / 0 °C / Inert atmosphere

4.2: 20.5 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; In diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;