N-Benzyl-2-oxopropanamide

Base Information

• Chemical Name: N-Benzyl-2-oxopropanamide
• CAS No.: 68259-66-5
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• European Community (EC) Number: 833-344-2
• Nikkaji Number: J778.343D
• Mol file: 68259-66-5.mol

Synonyms:N-Benzyl-2-oxopropanamide;68259-66-5;SCHEMBL7563589;EN300-6734888

Chemical Property of N-Benzyl-2-oxopropanamide

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 195

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C(=O)NCC1=CC=CC=C1

Technology Process of N-Benzyl-2-oxopropanamide

There total 7 articles about N-Benzyl-2-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-oxo-N-phenyl-N-tosylpropanamide + benzylamine (100-46-9) → N-benzyl-2-oxopropanamide (68259-66-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1039/d1ob01021b

Reference yield: 87.0%

C3H3NOS2 + benzylamine (100-46-9) → N-benzyl-2-oxopropanamide (68259-66-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.mencom.2009.03.010 DOI:10.1016/j.tet.2010.04.033

Reference yield: 73.0%

(S)-N-benzyl-2-hydroxypropionamide (103808-45-3) → N-benzyl-2-oxopropanamide (68259-66-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

2-oxo-propionic acid

benzylamine

propynoic acid benzylamide

(S)-N-benzyl-2-hydroxypropionamide