Technology Process of (E)-tert-butyl 3-(4-(aminomethyl)phenyl)acrylate hydrochloride
There total 6 articles about (E)-tert-butyl 3-(4-(aminomethyl)phenyl)acrylate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C14H17N3O2;
With
water; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
hexanes; diethyl ether;
DOI:10.1016/j.bmc.2010.06.081
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere
2.1: sodium tetrahydroborate / ethanol / 20 °C
3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
4.1: sodium azide / N,N-dimethyl-formamide / 20 - 50 °C
4.2: 20 °C
5.1: hydrogenchloride / hexanes; diethyl ether / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
tetrahydrofuran; hexanes; diethyl ether; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere
2.1: sodium tetrahydroborate / ethanol / 20 °C
3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
4.1: sodium azide / N,N-dimethyl-formamide / 20 - 50 °C
4.2: 20 °C
5.1: hydrogenchloride / hexanes; diethyl ether / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
tetrahydrofuran; hexanes; diethyl ether; ethanol; N,N-dimethyl-formamide;
